Efficacy of VAX-D on chronic low back pain: Study of dosage regimen
Gustavo Ramos M.D., Department of Neurology and Radiology
Rio Grande Regional Hospital, McAllen Texas
(page four of six)
Table 2: Frequency Distribution of Response
| Response |
Diagnosis - Confirmed by Diagnostic Imagining |
| 20 Sessions |
10 Sessions |
| Cases |
% |
Cases |
% |
| Remission |
39 |
76.5 |
39 |
42.9 |
| Partial Remission |
10 |
19.6 |
22 |
24.1 |
| Negative |
2 |
3.9 |
30 |
32.9 |
| Total Cases |
51 |
0 |
91 |
|
|
Table 3 shows the responses classed conservatively into two categories Remission and Not-Remission. For this purpose " Not-Remission " includes all cases classed as both Partial Responses and Negative Responses. The difference between the two dosage groups was found to be highly significant with a p < 0.0002.
Table 3: Frequency Distribution of Response
| Response |
Diagnosis - Confirmed by Diagnostic Imagining |
| 20 Sessions |
10 Sessions |
| Cases |
% |
Cases |
% |
| Remission |
39 |
76.5 |
39 |
42.9 |
| Not Remission* |
12 |
23.5 |
52 |
57.1 |
| Total Cases |
51 |
0 |
91 |
|
|
*Not-Remission = ( Partial Remission + Negative response )
Chi-Square = 19.14 p < .0002 @ df 1
The 20 Sessions group achieved a statistically significant: 1. Higher remission rate 2. Lower failure rate
Analysis of the Remission rate and Not-Remission rate was then subjected to null hypothesis as shown in Tables 4 and 5. "Null hypothesis" employs a stringent criteria based on the concept that if the procedure has no effect the frequency distribution would be equal between categories of response. Statistical analysis was performed to compare the observed frequency distribution and a normal binomial distribution.
Table 4 shows the responses classed as Remission and Not-Remission, for the 20 Sessions group compared to a null hypothesis distribution. Chi- Square analysis of this data concludes that the Remission rate in the 20 Sessions group was statistically significant with a p < 0.01.
Table 5. shows the responses classed as Remission and Not-Remission, for the 10 Sessions group compared to a null hypothesis distribution. Chi- Square analysis of this data was not statistically significant with a p > 0.3 .
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